This spider buries itself in the sand and strikes from ambush at prey that wanders too closely. Sand particles adhere to cuticles on its abdomen, thus acting as a natural camouflage if uncovered. If disturbed, it will run a short distance and bury itself again. The six-eyed spider has a poor sense of direction, unlike other species of spiders.
The Six Eyed Sand Spider is covered in small hairs, called setae (a stiff hair, bristle or bristle-like process or part of an organism), which serve to hold particles of sand. This provides effective camouflage even when the spider is not buried.
The Six Eyed Sand Spider has a body length up to 0.6 inches (15 millimetres) and the width across the legs is about 2 inches (50 millimetres). Most species are reddish-brown to yellow in colour without any distinct patterns. Six Eyed Sand Spiders often camouflage themselves with sand particles wedged between body hairs in order to blend into the background of their specific habitat. The Six Eyed Sand Spiders are shy and secretive, however, they will bite when accidentally contacted.
Toxicology studies have demonstrated that the venom is particularly potent, with a powerful hemolytic/necrotoxic effect, causing blood vessel leakage, thinning of the blood and tissue destruction. Sicarius bite treatment should be directed, as with all cytotoxic bites, at prevention of secondary infection and combating Disseminated intravascular coagulation (DIC) if it develops. No anti-venom exists for it.