This species is of interest because of the pathogens it carries, and its salivary apyrases which prevent platelet activation and aggregation, that is, blood-clotting. In humans the tick may cause dermatitis, fever and lymphadenitis. It is also a carrier of Borrelia, a spirochaete bacterium, and is a carrier of a flavivirus causing Alkhurma hemorrhagic fever (AHFV). The closely related Kyasanur Forest disease virus (KFDV) is endemic to certain regions of India. That AHFV and KFDV diverged some 700 years ago would suggest that unknown tick-borne hemorrhagic/encephalitic viruses may exist between Saudi Arabia and India.
Soft ticks of the family Argasidae lack the hard scutum or shield present in hard ticks of the family Ixodidae. Their gnathosoma or mouth structure is located on the underside of the body and is not readily visible. Their feeding method differs from that of the hard ticks in that they do not embed a capitulum in the host, but make an incision through the skin and sip the oozing blood. The feeding lasts up to 30 minutes during which time their body weight may increase as much as tenfold. Sand tampans by their concerted attack in large numbers are able to paralyse and kill sizeable mammals, especially penned livestock, by introducing toxins during feeding, mainly through coxal gland secretions, leading to symptoms similar to those of anaphylactic shock in older animals. These toxins affect the cardiac system, causing Mobitz type atrial-ventricular blocks and ventricular tachycardia. The defensins employed by O. savignyi are being studied for developing multifunctional peptides - shorter peptides derived from the defensin isoform 2 (OsDef2) have useful antibacterial, antioxidant, and cytotoxic properties.
Ornithodoros spp are found worldwide in semi-arid regions, living in burrows, caves, dens, cliffsides, and bird colonies. O. savignyi and O. coriaceus are exceptional in having eyes. O. coriaceus occurs under hillside scrub oak from northern California and Nevada to Mexico, in deer beds under trees and in the lee of large rocks. O. gurneyi favors tree-shaded sand in the deserts of Australia, resting places of kangaroos and people. O. porcinus is found on warthogs, bushpigs and other pig species and occurs throughout Africa in suitable habitats - it plays a role in transmitting the virus causing African swine fever which in 2013 was found 35 km north of Pretoria. A salticid spider, Phidippus rimator, has been recorded from northern California as predating Ornithodoros coriaceus and is only the second predator recorded for this species.
O. savignyi was named after the zoologist Marie Jules César Lelorgne de Savigny, a contemporary of Jean Victoire Audouin's.
Since they are attracted by carbon dioxide, dry ice may be used for their collection, or they may be sifted from the soil. Ornithodoros tampans also fluoresce under ultraviolet light.
The extensive distribution of this species from Africa to Asia strongly suggests anthropogenic origins. "Dispersal of the ancestral viruses of AHFV and KFDV may have been accomplished through the movement of animals, including camels presumably carrying ticks, along the Silk Road, which by the 1300s stretched from Europe to China."
The coxal secretion of adult female ticks, appearing during and after a blood meal, contains a sex pheromone provoking a mating response from males. Mating occurs off the host, hard ticks doing so on the host animal. Females lay a few hundred eggs in several batches, and may do so for several seasons—adults of Ornithodoros erraticus can live for 15–20 years (Encinas Grandes et al. 1993). There is little seasonal fluctuation in their numbers as their microhabitats are quite stable.