It is very widespread in America ranging from Texas to central Wisconsin in the Midwest and east to the coast where it can be found as far north as Maine, as far south as Guatemala, and sightings of this species have been reported in Québec, Colombia and Ecuador. It is most common in wooded areas, particularly in forests with thick underbrush, and large trees.
The tick follows the normal development stages of egg, larva, nymph and adult. It is known as a 3-host tick, meaning that it feeds from a different host during the larval, nymphal, and adult stages. The lone star tick attaches itself to a host by way of questing.